Robert Meeting Talk November 22nd 2013

Biofilm production, quorum sensing, and association with decidual cells in GBS

Some papers of interest in this area:

Bishart et al 2004 Hyperinvasive Neonatal Group B Streptococcus Has Arisen from a Bovine Ancestor

Bishart et al 2005 Population structure of group B streptococcus from a low-incidence region for invasive neonatal disease

Davies et al 2004 Multilocus Sequence Typing of Serotype III Group B Streptococcus and Correlation with Pathogenic Potential

Maisey et al 2008 Recent advances in understanding the molecular basis of group B Streptococcus virulence

Kleerebezem et al 1997 Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria

Ulrich et al 2005 One-component systems dominate signal transduction in prokaryotes

Interplay of each system in biofilm formation:

|:————-:|:————-:| |Cov R/S|Dlt A/C| |Cia R/C|Rgf A/C|

More on the Rgf Operon - Al Safadi et al 2011 Two-Component System Rgf A/C Activates the fbsB Gene Encoding Major Fibrinogen-Binding Protein in Highly Virulent CC17 Clone Group B Streptococcus

Review by Waters & Bassler 2005 Quorum Sensing: Cell-to-Cell Communication in Bacteria

More on GBS Biofilms - Kaur et al 2009 Biofilm formation in clinical isolates of group B streptococci from north India

Patients with symtomatic low biofilm production is a negative predictor for disease?

CFCS –> what are the risidual contents of the CFCS? One way to address this would be HPLC.


22 November 2013